{"id":1576,"date":"2022-04-01T09:34:16","date_gmt":"2022-04-01T09:34:16","guid":{"rendered":"https:\/\/translate.peaches.es\/peaches-biotech-deciphers-communication-language-between-immune-cells-and-other-tissues\/"},"modified":"2022-04-01T09:34:16","modified_gmt":"2022-04-01T09:34:16","slug":"peaches-biotech-deciphers-communication-language-between-immune-cells-and-other-tissues","status":"publish","type":"post","link":"https:\/\/peaches.es\/en\/peaches-biotech-deciphers-communication-language-between-immune-cells-and-other-tissues\/","title":{"rendered":"Peaches Biotech deciphers communication language between immune cells and other tissues"},"content":{"rendered":"<p>Peaches Biotech publishes in Biomolecules its work on how the immune system communicates with tissues damaged or attacked by viruses or bacteria.<\/p>\n<ul>\n<li>This breakthrough opens a way to find new drugs, of biological origin, of great importance in advanced therapies such as immunomodulators, anti-inflammatories and tissue regenerators.<\/li>\n<li>The first drug based on this work will be tested to combat cytokine storm in COVID-19 patients. Subsequently in those caused by other septic infections or pancreatitis.<\/li>\n<li>Peaches Biotech&#8217;s drug belongs to the new generation of complex biological drugs that come from co-culture methods in which the communication between macrophages and damaged tissue cells is reproduced.<\/li>\n<li>The treatment has shown efficacy and safety in animal models as anti-inflammatory, immunomodulatory and regenerative.<\/li>\n<li>A clinical trial to treat cytokine storm in patients with COVID-19 will be initiated soon.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Madrid, April 1, 2022. <a href=\"https:\/\/peaches.es\/\"><br \/>\n  <strong>Peaches Biotech Group<\/strong><br \/>\n<\/a>Peaches Biotech, a Spanish company specialized in innovative treatments in regenerative medicine and advanced therapies, announces the publication of <strong>an article in the journal Biomolecules of the scientific publishing group MDPI <\/strong>entitled &#8220;<em>Production of a new anti-inflammatory biological drugs<\/em>&#8220;. The publication reports his work based on the communication between macrophages and mesenchymal cells with which he will develop his first immunomodulatory and anti-inflammatory biologic drug that will treat the cytokine storm.<\/p>\n<p>The article explains how the company Peaches Biotech <strong>has deciphered the language with which immune cells communicate with different tissues<\/strong>. This scientific contribution is of great relevance, since it opens a new avenue for obtaining drugs of biological origin that will lead to more effective therapies in highly prevalent pathologies that currently lack effective treatments.<\/p>\n<p>As demonstrated in Biomolecules, intercellular communication between macrophages and cells involved in tissue regeneration, such as adult mesenchymal stromal cells and primary tissue cells, is essential for tissue regeneration.<\/p>\n<p>To understand this communication and get the message, between immune cells &#8211; macrophages &#8211; and tissue cells damaged or attacked by pathogens, Peaches Biotech reproduces in a cell co-culture medium the conditions that occur in our own body.<\/p>\n<h2><strong>Peaches Biotech&#8217;s co-cultivation concept<\/strong><\/h2>\n<p>The message between M2 macrophages and tissue cells is composed of a complex set of cytokines, chemokines and growth factors that form the secretome of the co-culture and will give rise to the new drug. It is this intercellular communication that drives an immunomodulatory and anti-inflammatory response.<\/p>\n<p>The first of these new drugs, which Peaches Biotech is working with, is <strong>PRS\u00ae CK-Storm<\/strong> and comes from the co-culture of M2 macrophages with adult mesenchymal stem cells (MSC).<\/p>\n<p>The PRS\u00ae CK-Storm will soon begin trials in several hospitals in the Madrid region.<\/p>\n<p>for the treatment of cytokine storm, initially in patients with COVID-19.<\/p>\n<p>PRS\u00ae CK-Storm not only combats the proinflammatory cytokine response, but also enhances the regenerative activity of damaged lung tissue after the disease in covid patients.<\/p>\n<p>This same method would apply to other pathologies where cytokine storms occur as in pancreatitis or those produced by other septic infections.<\/p>\n<p><strong><em>About the cytokine storm<\/em><\/strong><\/p>\n<p>Inflammation is the response of an organism&#8217;s immune system to damage caused to its cells and tissues by bacterial pathogens or any other biological, chemical, physical or mechanical aggressor. Such an inflammatory response must be self-limiting in time and intensity because, if this is not the case and if there is not perfect coordination between our innate and adaptive immune systems, a severe inflammatory syndrome with feedback will occur, eventually causing a cytokine storm that can lead to multi-organ failure. Peaches Biotech has been able to neutralize the pro-inflammatory reaction produced by this overreaction of the immune system in both in vitro and animal models.<\/p>\n<p>Link to article: <a href=\"https:\/\/www.mdpi.com\/2218-273X\/12\/4\/534\">Biomolecules<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peaches Biotech publishes in Biomolecules its work on how the immune system communicates with tissues damaged or attacked by viruses or bacteria. This breakthrough opens a way to find new drugs, of biological origin, of great importance in advanced therapies such as immunomodulators, anti-inflammatories and tissue regenerators. The first drug based on this work will [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1433,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false},"categories":[45,43],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.10 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Peaches Biotech deciphers communication language between immune cells and other tissues - Peaches Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peaches.es\/en\/peaches-biotech-deciphers-communication-language-between-immune-cells-and-other-tissues\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Peaches Biotech deciphers communication language between immune cells and other tissues - Peaches Biotech\" \/>\n<meta property=\"og:description\" content=\"Peaches Biotech publishes in Biomolecules its work on how the immune system communicates with tissues damaged or attacked by viruses or bacteria. 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