{"id":1582,"date":"2021-05-12T14:42:41","date_gmt":"2021-05-12T14:42:41","guid":{"rendered":"https:\/\/translate.peaches.es\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/"},"modified":"2021-05-12T14:42:41","modified_gmt":"2021-05-12T14:42:41","slug":"reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion","status":"publish","type":"post","link":"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/","title":{"rendered":"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion."},"content":{"rendered":"<div class=\"article-citation\">\n<div>Published by <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29369778\/\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed<\/a><\/div>\n<div><\/div>\n<div class=\"article-source\"><span class=\"cit\">2018 Apr;1869(2):103-116.<\/span><\/div>\n<p><span class=\"citation-doi\">doi: 10.1016\/j.bbcan.2017.12.001.<\/span> <span class=\"secondary-date\">Epub 2018 Jan 31.<\/span><\/p>\n<\/div>\n<h3>Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion.<\/h3>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<div class=\"authors-list\"><span class=\"authors-list-item \">Yasuhiro Saito<sup class=\"affiliation-links\"><span class=\"author-sup-separator\"> <\/span><\/sup><span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">Ridhdhi R Desai<sup class=\"affiliation-links\"><span class=\"author-sup-separator\"> <\/span><\/sup><span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">Senthil K Muthuswamy<sup class=\"affiliation-links\"><span class=\"author-sup-separator\"> <\/span><\/sup><\/span> <\/div>\n<\/div>\n<\/div>\n<div class=\"short-article-details\">Affiliations &#8211; <span class=\"id-label\">PMID: <\/span><strong class=\"current-id\" title=\"PubMed ID\">29369778 &#8211; <\/strong><span class=\"id-label\">DOI: <\/span>10.1016\/j.bbcan.2017.12.001<\/div>\n<\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h3 class=\"title\">Abstract<\/h3>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<div id=\"abstract\" class=\"abstract\">\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Cell polarity is a fundamental property used to generate asymmetry and structure in all cells. Cancer is associated with loss of cell and tissue structure. While observations made in model system such as Drosophila, identify polarity regulators as tumor suppressors that cause inappropriate cell division, studies in mammalian epithelia do not always support such a causative contribution. Our analysis of published cancer dataset shows that many polarity genes, including PARD6B, SCRIB, PRKCI, DLG1, DLG2, DLG5 and LLGL2, are frequently amplified in multiple cancers raising the possibility that mammalian epithelia may have evolved to use polarity proteins in multiple ways where they may have tumor promoting functions. In this review, we reinterpret the published results and propose a modified perspective for the role of polarity regulators in cancer biology. In addition to the traditional form of cell polarity, which is involved establishment of maintenance of normal cell structure and asymmetry, we propose that some mammalian polarity proteins also regulate subcellular polarity (intracellular asymmetry), which can improve cellular fitness to carry out functions such as proliferation, apoptosis, stress adaptation, stemness and organelle biology. Here, we define subcellular polarity and discuss evidence that supports a role for subcellular polarity in biology.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords: <\/strong>Cancer; Cell polarity; Subcellular polarity.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">Copyright \u00a9 2018 Elsevier B.V. All rights reserved.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Published by PubMed 2018 Apr;1869(2):103-116. doi: 10.1016\/j.bbcan.2017.12.001. Epub 2018 Jan 31. Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. Yasuhiro Saito , Ridhdhi R Desai , Senthil K Muthuswamy Affiliations &#8211; PMID: 29369778 &#8211; DOI: 10.1016\/j.bbcan.2017.12.001 Abstract Cell polarity is a fundamental property used to generate asymmetry and structure in [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1413,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false},"categories":[43],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.10 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. - Peaches Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. - Peaches Biotech\" \/>\n<meta property=\"og:description\" content=\"Published by PubMed 2018 Apr;1869(2):103-116. doi: 10.1016\/j.bbcan.2017.12.001. Epub 2018 Jan 31. Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. Yasuhiro Saito , Ridhdhi R Desai , Senthil K Muthuswamy Affiliations &#8211; PMID: 29369778 &#8211; DOI: 10.1016\/j.bbcan.2017.12.001 Abstract Cell polarity is a fundamental property used to generate asymmetry and structure in [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/\" \/>\n<meta property=\"og:site_name\" content=\"Peaches Biotech\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-12T14:42:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peaches.es\/wp-content\/uploads\/2021\/05\/img_dest_blog_pubmed.png\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Comunicacion\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Comunicacion\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/\",\"url\":\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/\",\"name\":\"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. - Peaches Biotech\",\"isPartOf\":{\"@id\":\"https:\/\/peaches.es\/en\/#website\"},\"datePublished\":\"2021-05-12T14:42:41+00:00\",\"dateModified\":\"2021-05-12T14:42:41+00:00\",\"author\":{\"@id\":\"https:\/\/peaches.es\/en\/#\/schema\/person\/334e7bfacc773dc5c5108d96a295621c\"},\"breadcrumb\":{\"@id\":\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/peaches.es\/en\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/peaches.es\/en\/#website\",\"url\":\"https:\/\/peaches.es\/en\/\",\"name\":\"Peaches Biotech\",\"description\":\"Al servicio de la salud y la biotecnolog\u00eda\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/peaches.es\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/peaches.es\/en\/#\/schema\/person\/334e7bfacc773dc5c5108d96a295621c\",\"name\":\"Comunicacion\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/peaches.es\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/643535d44155ed63870ee02f7415d463?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/643535d44155ed63870ee02f7415d463?s=96&d=mm&r=g\",\"caption\":\"Comunicacion\"},\"url\":\"https:\/\/peaches.es\/en\/author\/comunicacion\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. - Peaches Biotech","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/peaches.es\/en\/reinterpreting-polarity-and-cancer-the-changing-landscape-from-tumor-suppression-to-tumor-promotion\/","og_locale":"en_US","og_type":"article","og_title":"Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. - Peaches Biotech","og_description":"Published by PubMed 2018 Apr;1869(2):103-116. doi: 10.1016\/j.bbcan.2017.12.001. 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